United States securities and exchange commission logo

                           July 17, 2020

       Carl Schwartz
       Chief Executive Officer
       Predictive Oncology Inc.
       2915 Commers Drive, Suite 900
       Eagan, MN 55121

                                                        Re: Predictive Oncology
Statement on Form S-3
                                                            Filed July 14, 2020
                                                            File No. 333-239851

       Dear Mr. Schwartz:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jason L.
Drory at 202-551-8342 with any questions.


                           Division of Corporation Finance

                           Office of Life Sciences
       cc:                                              Bradley L. Yenter, Esq.