November 13, 2019

Bob Myers
Chief Financial Officer
Predictive Oncology Inc.
2915 Commers Drive, Suite 900
Eagan, MN 55121

       Re: Predictive Oncology Inc.
           Registration Statement on Form S-1
           Filed October 30, 2019
           File No. 333-234366

Dear Mr. Myers:

       We have limited our review of your registration statement to those
issues we have
addressed in our comment.

       Please respond to this letter by amending your registration statement
and providing the
requested information. If you do not believe our comment applies to your facts
and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

       After reviewing any amendment to your registration statement and the
information you
provide in response to this comment, we may have additional comments.

Form S-1 filed on October 30, 2019

Additional Risk Factor, page 6

1.     We note the additional risk factor you have provided addressing your
Exclusive Forum
       Provision under Delaware law. To avoid the possibility of any confusion,
please revise
       sentence two of the risk factor to clarify, if true, that your exclusive
forum selection
       provision does not apply to actions arising under the Securities Act of
1933, as amended,
       or the Securities Exchange Act of 1934, as amended.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
 Bob Myers
Predictive Oncology Inc.
November 13, 2019
Page 2

statement.

       Please contact Paul Fischer at 202-551-3415, or Mary Beth Breslin at
202-551-3625, with
any other questions.



                                                          Sincerely,
FirstName LastNameBob Myers
                                                          Division of
Corporation Finance
Comapany NamePredictive Oncology Inc.
                                                          Office of Life
Sciences
November 13, 2019 Page 2
cc:       Martin Rosenbaum, Esq.
FirstName LastName