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After this split was approved, additional options and warrants were identified, requiring a second reverse stock split in order to reach the 1,920,000 shares. The second reverse stock split on the reduced 1-for-1.2545 balance was determined to be 1-for-1.33176963. Taken together, if only one reverse stock split was performed, the number would have been a reverse stock split of 1-for-1.670705. On June 6, 2008, the Board of Directors approved the first reverse stock split. The authorized number of shares of common stock of 20,000,000 was proportionately divided by 1.2545 to arrive at 15,942,607. On October 20, 2008, the Board of Directors (i) approved the second reverse stock split pursuant to which the authorized number of shares of common stock of 15,942,607 was proportionately divided by 1.33177 to arrive at 11,970,994 shares and (ii) approved a resolution to increase the number of authorized shares of the Company''''s common stock from 11,970,994 to 40,000,000, which was approved by the Company''''s shareholders holding a majority of the shares entitled to vote thereon at a special meeting of shareholders held on December 3, 2008." 172489 1937638 -1352709 -654114 -1518933 -4486879 -11868956 -2855775 -5704855 -17573810 12771683 27236303 22193681 24282433 5805714 79467603 55370243 9608160 0 0 0 0 0 12771683 27236303 22193681 24282433 5805714 79467603 55370243 9608160 14169143 31298440 32679862 45250929 1579000 2626000 3957000 56000 49000 28000 1635000 2675000 3985000 1635000 2675000 3985000 0 0 0 1.00 1.00 11254000 16959000 will begin to expire in 2017 will begin to expire in 2017 0.1025 lower of $0.90 2012-06-20 1063056 132371 9571 19298 0 90610 87640 100000 0 0 100000 457300 0 0 50000 6000 10267 1460714 63000 100000 185069 10000 0 457300 11840 89300 37500 126046 98659 32000 100000 0 0 50000 100000 648100 0 100000 200000 10000 0 16800 89300 0 0 100000 32000 0 0 100000 66267 830561 558800 1084300 100000 1516082 457300 0 89300 89300 9390 67629 7229 12702 12360 1341 0 14931 4960 23954 0 0 0 0 0 0 0.1025 0.12 0.08 0.50 0.10 0.10 0.10 0.08 0.06 0.08 0.10 0.08 0.12 0.08 0.06 0.12 0.08 0.12 0.08 0.10 0.12 0.06 0.08 0.10 0.08 0.12 0.1025 0.08 0.06 0.12 0.08 285715 285715 0.35 0.18 0.10 0.84 0.15 0.35 0.18 0.15 0.18 0.084 0.35 0.18 0.1 0.84 0.15 0.35 0.18 0.35 0.18 0.084 24 month 24 month 0.55 0.50 0.60 0.50 0.02 967 20000 30000 208 280 0 16800 1275 31000 26000 five years five years 49863 37095 49975 39593 0.50 0.08 0.50 0.08 0.08 0.50 0.35 0.08 0.50 0.65 0.01 0.65 0.01 0.01 0.65 0.46 0.01 0.65 479910 169854 39743 12698 702205 25553 31332 31506 790596 -390368 -88290 61934 868772 20847 -4689 6293 147403 -738 -1562 1618 40419 617 -724 556 12053 -5571 3209 25014 -6122 3247 30740 -44160 1420 20891 -369642 -151118 78276 1145292 89796 870278 27862 1506 6293 149007 0 1604 1624 40481 6 62 752 12081 196 28 1071847 6109 2900 539 6714 3467 592 54775 53355 10615 166063 1071847 87787 14946 479910 486564 6654 25000 3000000 30000 3000000 2000 46000 4000 0.2000 240000 156243 1546667 7500000 277778 0.09 30000 0.15 4615385 12000 0.014 0.065 0.15 0.07 (1) Founders shares, 1,000,000 pre-split (2) 23,492 (40,000 pre-split) shares valued at $.0167 per share as compensation for loan guarantees by management (5) Compensation for loan guarantees by management (3) Investment including 670 shares issued as a 10% finders fee (4) For payment of patent legal fees (6) For vendor contractual consideration (7) Employment agreements (8) Investment (10) Investment, "October 2008 financing". (9) Conversion of convertible notes by management Adjusted for the reverse stock splits in total at June 6, 2008 and October 20, 2008. The number of shares underlying options and warrants outstanding as of December 31, 2011 and December 31, 2010 are 32,679,862 and 14,169,143, respectively. The effect of the shares that would be issued upon exercise of such options and warrants has been excluded from the calculation of diluted loss per share because those shares are anti-dilutive. The number of shares underlying options and warrants outstanding as of September 30, 2012 and September 30, 2011 are 45,250,929and 31,298,440 respectively. The effect of the shares that would be issued upon exercise of such options and warrants has been excluded from the calculation of diluted loss per share because those shares are anti-dilutive. The short-term notes have all matured except for the $16,800 that matures in December 2012. The Company is currently negotiating with the note holders. 599 6 994 1000 1593502 1547974 45528 4552862 -1250 1250 125000 0 4130 4130 160000 0.35 75000 0.35 0001446159us-gaap:BoardOfDirectorsChairmanMember2011-01-012011-12-31 0001446159us-gaap:DirectorMember2011-01-012011-12-31 25000 30000 357282 26500000 26500000 00014461592012-08-012012-08-31 0.2000 600000 155000 0001446159bior:RelatedPartyMember2011-12-31 46000 2000 3000000 0.02 0.045 0.00 P7Y6M P2Y6M 0.0120 0.1090 P2Y Stock options and warrants expire on various dates from February 2012 to July 2021. Stock options and warrants expire on various dates from October 2012 to September 2022. 2012-03-31 0.0325 0.075 0.25 0001446159us-gaap:MinimumMemberbior:StockOptionsFiveMember2011-01-012011-12-31 0001446159us-gaap:MaximumMemberbior:StockOptionsFiveMember2011-01-012011-12-31 0.075 0.25 9514286 300000 600000 1.67 0.63 0.46 0.35 0.22 0.50 0001446159bior:StockOptionsAndWarrantsMember2012-01-012012-09-30 0001446159bior:StockOptionsAndWarrantsOneMember2012-01-012012-09-30 0001446159bior:StockOptionsAndWarrantsTwoMember2012-01-012012-09-30 0.0038 0.00 0.54 0.59 0.66 P3Y P5Y P10Y 438000 P2Y6M 0.102 0.336